Cellular and Molecular Neurobiology<\/p>\n
Author:<\/strong> Maria Mercedes Benedetto | Email:<\/strong> mbenedetto@immf.uncor.edu<\/p>\n Maria Mercedes Benedetto 1\u00b0<\/sup>, Julieta Agostina Cettra-Zarate 1\u00b0<\/sup>, Osvaldo Mart\u00edn Basmadjian 1\u00b0<\/sup>, Maria Julia Cambiasso 2\u00b0<\/sup>, Maria Gabriela Paglini 3\u00b0<\/sup><\/p>\n 1\u00b0 Instituto de Investigaci\u00f3n M\u00e9dica Mercedes y Mart\u00edn Ferreyra, INIMEC-CONICET,Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina Drug addiction is a chronic brain disorder triggered by repeated exposure to drugs. There is increasing evidence for sex differences in many aspects of drug addiction including vulnerability, withdrawal and treatment outcome. Behavioral sensitization, characterized by a progressive and persistent increase of specific behaviors following repetitive drug exposure, has garnered attention. Also, neuroadaptive responses underlying drug abuse would involve synaptic plasticity, a mechanism regulated by sex steroids. Given this, we aimed to study sex differences in behavioral sensitization and neuronal plasticity associated with Amphetamine (Amph) exposure.To address this, male and female thy-1 eGFP mice of 21 and 33 days (PN) were treated with Amph or vehicle and the locomotion was recorded. After 1 day of withdrawal, subjects were challenged with the same administration protocol to evaluate sensitization. Brain samples were collected four hours after the last Amph exposure to analyze dendritic spines of hippocampal pyramidal neurons. We observed that acute Amph induced greater hyperlocomotion in females than in males at PN21. Behavioral sensitization was observed in females at PN23 and in males at PN35, highlighting differences across sexes at both ages studied. Also, acute exposure to Amph increased the number of stubby spines in males at PN23. These results provide insight into the sexual dimorphism in behavioral responses and synaptic plasticity associated with Amph exposure.<\/p>\n","protected":false},"excerpt":{"rendered":" Author: Benedetto Maria Mercedes | email: mbenedetto@immf.uncor.edu | Cellular and Molecular Neurobiology<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[18],"class_list":["post-1228","post","type-post","status-publish","format-standard","hentry","category-session-1","tag-cellular-and-molecular-neurobiology"],"_links":{"self":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1228","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/comments?post=1228"}],"version-history":[{"count":3,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1228\/revisions"}],"predecessor-version":[{"id":1693,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1228\/revisions\/1693"}],"wp:attachment":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/media?parent=1228"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/categories?post=1228"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/tags?post=1228"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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\n2\u00b0 C\u00e1tedra de Biolog\u00eda Celular, Facultad de Odontolog\u00eda, Universidad Nacional de C\u00f3rdoba, Argentina
\n3\u00b0 Instituto de Virolog\u00eda “Dr. J.M.Vanella”, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de C\u00f3rdoba, Argentina<\/p>\n