{"id":1281,"date":"2023-09-26T15:01:39","date_gmt":"2023-09-26T18:01:39","guid":{"rendered":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/2023\/09\/26\/109-early-life-stress-due-to-infant-maltreatment-reshapes-stress-response-behavior-in-adult-rats\/"},"modified":"2023-09-28T18:17:21","modified_gmt":"2023-09-28T21:17:21","slug":"109-early-life-stress-due-to-infant-maltreatment-reshapes-stress-response-behavior-in-adult-rats","status":"publish","type":"post","link":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/2023\/09\/26\/109-early-life-stress-due-to-infant-maltreatment-reshapes-stress-response-behavior-in-adult-rats\/","title":{"rendered":"109 | Early-life stress due to infant maltreatment reshapes stress-response behavior in adult rats"},"content":{"rendered":"<p>Cognition, Behavior, and Memory<\/p>\n<p><strong>Author:<\/strong> Jazm\u00edn Grillo Balboa | <strong>Email:<\/strong> jazmin.grillo28@gmail.com<\/p>\n<hr \/>\n<p>Jazm\u00edn Grillo Balboa <sup>1\u00b0<\/sup>, Ail\u00e9n Alba Colapietro <sup>1\u00b0<\/sup>, Ver\u00f3nica Cantarelli <sup>2\u00b0<\/sup>, Marina Ponzio <sup>2\u00b0<\/sup>, Mar\u00eda Eugenia Pallar\u00e9s <sup>1\u00b0<\/sup>, Mariela J. Chertoff <sup>3\u00b0<\/sup>, Marta Cristina Antonelli <sup>1\u00b0<\/sup><\/p>\n<p>1\u00b0 Instituto de Biolog\u00eda Celular y Neurociencia &#8220;Prof. E. De Robertis&#8221;, Facultad de Medicina, Universidad de Buenos Aires. Buenos Aires, Argentina<br \/>\n2\u00b0 Instituto de Investigaciones en Ciencias de la Salud (INICSA-CONICET), Facultad de Ciencias M\u00e9dicas, Universidad Nacional de C\u00f3rdoba. C\u00f3rdoba, Argentina<br \/>\n3\u00b0 IQUIBICEN-DQB, Facultad de Ciencias Exactas y Naturales &#8211; Universidad de Buenos Aires &#8211; CONICET, Argentina<\/p>\n<p>Early parental care is crucial for the proper development of the cortico-limbic circuits regulating the stress response and emotional well-being. Thus, infant maltreatment may lead to mood-related disorders, impairing individuals&#8217; capacity to deal with stress. Here, we employed the &#8220;Scarcity-adversity model&#8221; (SAM) in rats \u2212limiting the nesting resources during postnatal days (PND) 8-12\u2212 and studied its impact on maternal and adult offspring\u2019s behavior. While the SAM did not affect dam weight gain or fecal corticosterone metabolites, we did find a heightened maternal anxiety-like phenotype in the Elevated plus maze (EPM), shown by a reduced tendency to explore the open arms. Adult offspring underwent a series of anxiogenic tests to assess their reactivity to stress. SAM males showed a decreased locomotor activity in the Open field test; and an earlier, more prolonged time in immobility in the Forced swim test. SAM rats of both sexes exhibited an increased open-arm latency, lower closed-arm latency, and a tendency to decrease their risk-assessment behaviors in the EPM. These results suggest that the SAM protocol induces lasting alterations in the risk-taking behavior, reactivity to novelty and to acute stressors in rodents, with males being more vulnerable than females. Our findings underpin the crucial role of a nurturing early-life environment in fostering both mental and physical well-being later in life, thereby reducing the risk of psychopathology.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Author: Grillo Balboa Jazm\u00edn | email: jazmin.grillo28@gmail.com | Cognition, Behavior, and Memory<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[20],"class_list":["post-1281","post","type-post","status-publish","format-standard","hentry","category-session-1","tag-cognition-behavior-and-memory"],"_links":{"self":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1281","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/comments?post=1281"}],"version-history":[{"count":4,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1281\/revisions"}],"predecessor-version":[{"id":2306,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1281\/revisions\/2306"}],"wp:attachment":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/media?parent=1281"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/categories?post=1281"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/tags?post=1281"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}