{"id":1295,"date":"2023-09-26T15:01:41","date_gmt":"2023-09-26T18:01:41","guid":{"rendered":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/2023\/09\/26\/137-involvement-of-retrosplenial-cortical-7-nicotinic-acetylcholine-receptors-in-aversive-memory-processing\/"},"modified":"2023-09-28T18:03:40","modified_gmt":"2023-09-28T21:03:40","slug":"137-involvement-of-retrosplenial-cortical-7-nicotinic-acetylcholine-receptors-in-aversive-memory-processing","status":"publish","type":"post","link":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/2023\/09\/26\/137-involvement-of-retrosplenial-cortical-7-nicotinic-acetylcholine-receptors-in-aversive-memory-processing\/","title":{"rendered":"137 | Involvement of retrosplenial cortical \u03b17 nicotinic acetylcholine receptors in aversive memory processing"},"content":{"rendered":"<p>Cognition, Behavior, and Memory<\/p>\n<p><strong>Author:<\/strong> VERONICA PASTOR | <strong>Email:<\/strong> verpastor@fmed.uba.ar<\/p>\n<hr \/>\n<p>VERONICA PASTOR <sup>1\u00b0<\/sup>, CYNTHIA KATCHE <sup>1\u00b02\u00b0<\/sup><\/p>\n<p>1\u00b0 CONICET-Universidad de Buenos Aires, Instituto de Biolog\u00eda Celular y Neurociencia &#8220;Prof. Eduardo De Robertis&#8221; (IBCN), Buenos Aires, Argentina<\/p>\n<p>In the retrosplenial cortex (RSC), the role of cholinergic modulation via \u03b17 nicotinic receptors (nAChRs) and their involvement in memory is unknown. In recent years, the RSC has been shown to deteriorate in the early stages of Alzheimer&#8217;s disease (AD). Likewise, the cholinergic system has been postulated as one of those responsible for cognitive impairment in patients with AD. Great interest has arisen in the study of \u03b17 nAChRs as more specific targets for the treatment of this disease. For this reason, we aim to study the role of \u03b17 receptors of the RSC in memory processing. We infused a selective \u03b17 nAChRs antagonist into RSC to assess its role in different phases of aversive memory processing using an inhibitory avoidance task. We found that \u03b17 nAChRs are required for memory expression in the RSC. These results identify these receptors as key players in the expression of an aversive memory and highlight their significant potential as therapeutic targets for Alzheimer&#8217;s disease.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Author: PASTOR VERONICA | email: verpastor@fmed.uba.ar | Cognition, Behavior, and Memory<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[20],"class_list":["post-1295","post","type-post","status-publish","format-standard","hentry","category-session-1","tag-cognition-behavior-and-memory"],"_links":{"self":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1295","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/comments?post=1295"}],"version-history":[{"count":4,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1295\/revisions"}],"predecessor-version":[{"id":2295,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1295\/revisions\/2295"}],"wp:attachment":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/media?parent=1295"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/categories?post=1295"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/tags?post=1295"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}