{"id":1303,"date":"2023-09-26T15:01:41","date_gmt":"2023-09-26T18:01:41","guid":{"rendered":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/2023\/09\/26\/153-role-of-5-ht2ar-in-prefrontal-cortex-activity-and-plasticity-in-social-behavior\/"},"modified":"2023-09-26T20:29:34","modified_gmt":"2023-09-26T23:29:34","slug":"153-role-of-5-ht2ar-in-prefrontal-cortex-activity-and-plasticity-in-social-behavior","status":"publish","type":"post","link":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/2023\/09\/26\/153-role-of-5-ht2ar-in-prefrontal-cortex-activity-and-plasticity-in-social-behavior\/","title":{"rendered":"153 | Role of 5-HT2AR in prefrontal cortex activity and plasticity in social behavior"},"content":{"rendered":"<p>Cognition, Behavior, and Memory<\/p>\n<p><strong>Author:<\/strong> Agostina Belen Sacson | <strong>Email:<\/strong> agostina.sacson@gmail.com<\/p>\n<hr \/>\n<p>Agostina Sacson <sup>1\u00b0<\/sup>, Aldana Sanchez Sanda <sup>1\u00b0<\/sup>, Ramiro Comas Mutis <sup>2\u00b0<\/sup>, Marcelo Giachero <sup>1\u00b0<\/sup>, Gaston Calfa <sup>2\u00b0<\/sup>, Noelia Weisstaub <sup>1\u00b0<\/sup><\/p>\n<p>1\u00b0 Laboratorio de Cognicion Molecular, INCyT (U. Favaloro, INECO, CONICET)<br \/>\n2\u00b0 IFEC (UNC-CONICET)<\/p>\n<p>Serotonergic signalling has shown to be a key player in the modulation of social behavior. Specifically, serotonin type 2A receptors (5-HT2AR), known to be involved in a variety of behaviors, have also been linked to social cognition through the pathophysiology of different psychiatric and neurodevelopmental disorders, and its role in the mechanism of action of so-called \u0093prosocial\u0094 drugs. Our lab found that 5-HT2AR knockout (htr2a-\/-) had reduced discrimination indexes in the three-chambers social interaction test (SI) compared to wild types (htr2a+\/+) mice. By genetically restoring the expression of 5-HT2AR in the forebrain, mice reached discrimination indexes similar to htr2a+\/+. To further analyse the role of cortical 5-HT2AR in social behaviors, we used c-fos immunohistochemistry to indirectly gauge SI neural activity. Considering the potential developmental role of 5-HT2AR, we analysed the impact of the lack of 5-HT2AR&#8217;s expression on prefrontal cortex structural plasticity by studying dendritic spines. Preliminary data showed lower spine density in htr2a-\/- mice&#8217;s infralimbic prefrontal cortex, suggesting distinct structural plasticity. These findings suggest a possible role of 5-HT2AR in social behavior in adult mice that might be potentially tied to prefrontal cortex plasticity differences.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Author: Sacson Agostina Belen | email: agostina.sacson@gmail.com | Cognition, Behavior, and Memory<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[20],"class_list":["post-1303","post","type-post","status-publish","format-standard","hentry","category-session-1","tag-cognition-behavior-and-memory"],"_links":{"self":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1303","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/comments?post=1303"}],"version-history":[{"count":3,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1303\/revisions"}],"predecessor-version":[{"id":1784,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1303\/revisions\/1784"}],"wp:attachment":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/media?parent=1303"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/categories?post=1303"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/tags?post=1303"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}