{"id":1306,"date":"2023-09-26T15:01:42","date_gmt":"2023-09-26T18:01:42","guid":{"rendered":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/2023\/09\/26\/159-a-hiperexcited-state-of-the-basolateral-amygdala-complex-influences-the-changes-in-hippocampal-structural-plasticity-associated-with-the-fear-memory-destabilization-reconsolidation-process\/"},"modified":"2023-09-26T20:30:17","modified_gmt":"2023-09-26T23:30:17","slug":"159-a-hiperexcited-state-of-the-basolateral-amygdala-complex-influences-the-changes-in-hippocampal-structural-plasticity-associated-with-the-fear-memory-destabilization-reconsolidation-process","status":"publish","type":"post","link":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/2023\/09\/26\/159-a-hiperexcited-state-of-the-basolateral-amygdala-complex-influences-the-changes-in-hippocampal-structural-plasticity-associated-with-the-fear-memory-destabilization-reconsolidation-process\/","title":{"rendered":"159 | A hiperexcited state of the basolateral amygdala complex influences the changes in hippocampal structural plasticity associated with the fear memory destabilization\/reconsolidation process."},"content":{"rendered":"<p>Cognition, Behavior, and Memory<\/p>\n<p><strong>Author:<\/strong> Mar\u00eda Candela Sosa | <strong>Email:<\/strong> maria.candela.sosa@mi.unc.edu.ar<\/p>\n<hr \/>\n<p>Mar\u00eda Cnadela Sosa <sup>1\u00b0<\/sup>, Ramiro Comas Mutis <sup>1\u00b0<\/sup>, Melisa Riva Gargiulo <sup>1\u00b0<\/sup>, Crhistian Bender <sup>1\u00b0<\/sup>, Gast\u00f3n Calfa <sup>1\u00b0<\/sup><\/p>\n<p>1\u00b0 Departamento de farmacolog\u00eda Otto Orsingher-Instituto de Farmacolog\u00eda Experimental (CONICET)<\/p>\n<p>The occurrence of the destabilization\/reconsolidation process of a fear memory plays<br \/>\na pivotal role in the appearance of some symptoms of PTSD and other anxiety<br \/>\ndisorders.<br \/>\nIt is known that the basolateral complex of the amygdala (BLA) is a key area<br \/>\nmodulating such clinical manifestations. Interestingly, a hiperexcitability of this area<br \/>\nwas observed concomitantly with the stress exposure and with changes in the<br \/>\ndynamisms of hippocampal structural plasticity.<br \/>\nIn this work we seek to observe and reverse the impairment of the structural<br \/>\nplasticity of dorsal hippocampus due to a pharmacological hyperexcited state in the<br \/>\nBLA that emulates the behavioral and structural manifestations of the stress prior to<br \/>\nconditioning fear memory. Subsequently, intraperitoneal d-cycloserine (partial NMDA<br \/>\nreceptor agonist) was used prior to memory recall to reverse the behavioral and<br \/>\nsynaptic impairment.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Author: Sosa Mar\u00eda Candela | email: maria.candela.sosa@mi.unc.edu.ar | Cognition, Behavior, and Memory<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[20],"class_list":["post-1306","post","type-post","status-publish","format-standard","hentry","category-session-1","tag-cognition-behavior-and-memory"],"_links":{"self":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1306","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/comments?post=1306"}],"version-history":[{"count":3,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1306\/revisions"}],"predecessor-version":[{"id":1788,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1306\/revisions\/1788"}],"wp:attachment":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/media?parent=1306"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/categories?post=1306"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/tags?post=1306"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}