{"id":1311,"date":"2023-09-26T15:01:42","date_gmt":"2023-09-26T18:01:42","guid":{"rendered":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/2023\/09\/26\/169-infant-maltreatment-stress-alters-adrenal-gland-histology-in-a-rat-model\/"},"modified":"2023-09-26T20:33:52","modified_gmt":"2023-09-26T23:33:52","slug":"169-infant-maltreatment-stress-alters-adrenal-gland-histology-in-a-rat-model","status":"publish","type":"post","link":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/2023\/09\/26\/169-infant-maltreatment-stress-alters-adrenal-gland-histology-in-a-rat-model\/","title":{"rendered":"169 | Infant maltreatment stress alters adrenal gland histology in a rat model"},"content":{"rendered":"<p>Development<\/p>\n<p><strong>Author:<\/strong> Ailen Alba Colapietro | <strong>Email:<\/strong> ailencolapietro@gmail.com<\/p>\n<hr \/>\n<p>Ailen Alba Colapietro <sup>1\u00b0<\/sup>, Jazm\u00edn Grillo Balboa <sup>1\u00b0<\/sup>, Eleonora Regueira <sup>2\u00b0<\/sup>, Gladys Noem\u00ed Hermida <sup>2\u00b0<\/sup>, Ver\u00f3nica Cantarelli <sup>3\u00b0<\/sup>, Marina Ponzio <sup>3\u00b0<\/sup>, Silvina Laura Diaz <sup>4\u00b0<\/sup>, Marta Cristina Antonelli <sup>1\u00b0<\/sup><\/p>\n<p>1\u00b0 Laboratorio de Programaci\u00f3n Perinatal del Neurodesarrollo. Instituto de Biolog\u00eda Celular y Neurociencias &#8220;Prof. E. De Robertis&#8221;. Facultad de Medicina. Universidad de Buenos Aires. Buenos Aires, Argentina.<br \/>\n2\u00b0 Laboratorio de Biolog\u00eda de Anfibios &#8211; Histolog\u00eda Animal. Departamento de Biodiversidad y Biolog\u00eda Experimental. Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Buenos Aires, Argentina.<br \/>\n3\u00b0 Instituto de Investigaciones en Ciencias de la Salud. Facultad de Ciencias M\u00e9dicas. Universidad Nacional de C\u00f3rdoba. C\u00f3rdoba, Argentina.<br \/>\n4\u00b0 Laboratorio de Neurog\u00e9nesis Experimental. Instituto de Biolog\u00eda Celular y Neurociencias &#8220;Prof. E. De Robertis&#8221;. Facultad de Medicina. Universidad de Buenos Aires. Buenos Aires, Argentina.<\/p>\n<p>Infant maltreatment is a public health problem that affects a large part of the world population. In Argentina, 7 out of 10 children are subjected to violent discipline methods, including physical and psychological aggression. Early stress generates dysregulation of the stress response system; however, little is known about the impact of infant maltreatment stress on the adrenal glands, end effectors of the hormonal cascade that synthesize glucocorticoids. In this work, we used the scarcity-adversity model (SAM) in rats during postnatal days (PND) 8-12 to induce maternal maltreatment and evaluate histological parameters in the adrenal glands and serum corticosterone levels of Control and SAM offspring of PND 13 and PND 28. The analysis of the adrenocortical zones showed that, compared to the control rats, SAM pups had a greater thickness in the undifferentiated zone at both ages and a lower thickness of the zona fasciculata at PND 13. The cells of the zona fasciculata, which synthesize glucocorticoids, had a smaller cytoplasmic radius and the sinusoids in that zone were thicker in the SAM offspring compared to the Control ones at both ages. PND 13 SAM pups showed higher basal levels of corticosterone compared to controls. These results indicate a histological alteration in the adrenal glands of lactating SAM offspring that persists postweaning up to PND 28. This condition can affect the response of individuals to subsequent stress, compromising their health later in life.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Author: Colapietro Ailen Alba | email: ailencolapietro@gmail.com | Development<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[21],"class_list":["post-1311","post","type-post","status-publish","format-standard","hentry","category-session-1","tag-development"],"_links":{"self":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1311","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/comments?post=1311"}],"version-history":[{"count":3,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1311\/revisions"}],"predecessor-version":[{"id":1795,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1311\/revisions\/1795"}],"wp:attachment":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/media?parent=1311"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/categories?post=1311"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/tags?post=1311"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}