{"id":1316,"date":"2023-09-26T15:01:42","date_gmt":"2023-09-26T18:01:42","guid":{"rendered":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/2023\/09\/26\/179-effects-of-gonadal-hormones-absence-since-weaning-on-social-behavior-in-adult-female-mice\/"},"modified":"2023-09-28T09:17:02","modified_gmt":"2023-09-28T12:17:02","slug":"179-effects-of-gonadal-hormones-absence-since-weaning-on-social-behavior-in-adult-female-mice","status":"publish","type":"post","link":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/2023\/09\/26\/179-effects-of-gonadal-hormones-absence-since-weaning-on-social-behavior-in-adult-female-mice\/","title":{"rendered":"179 | Effects of gonadal hormones absence since weaning on social behavior in adult female mice"},"content":{"rendered":"<p>Disorders of the Nervous System<\/p>\n<p><strong>Author:<\/strong> Luc\u00eda Mar\u00eda Di Guardia Casella | <strong>Email:<\/strong> lmdiguardiacasella@gmail.com<\/p>\n<hr \/>\n<p>Luc\u00eda Mar\u00eda Di Guardia Casella <sup>1\u00b02\u00b0<\/sup>, Araceli Seiffe <sup>1\u00b0<\/sup>, Amaicha M. Depino <sup>1\u00b03\u00b0<\/sup><\/p>\n<p>1\u00b0 Instituto de Fisiolog\u00eda, Biolog\u00eda Molecular y Neurociencias (UBA-CONICET)<br \/>\n2\u00b0 Departamento de Fisiolog\u00eda, Biolog\u00eda Molecular y Celular (FCEN, UBA)<br \/>\n3\u00b0 Departamento de Biodiversidad y Biolog\u00eda Experimental (FCEN, UBA)<\/p>\n<p>Autism Spectrum Disorder (ASD) is characterized by decreased sociability and increased repetitive behaviors, with a significant sex bias: over 80% of ASD diagnoses are in males. This implicates sex-related factors in ASD development. Previous experiments from our group demonstrated that male mice prenatally exposed to VPA at GD12.5 exhibit reduced sociability at weaning and in adulthood. In contrast, VPA-exposed females display reduced juvenile play at postnatal day (PD) 21, but sociability remains unaffected in adulthood.<\/p>\n<p>To explore non-reproductive ASD-related behaviors influenced by gonadal hormones, we investigated adult female CF1 mice ovariectomized (OVX) or subjected to sham (SHAM) surgery at PD21. We then ran a battery of behavioral tests in adulthood, to evaluate ASD-relevant behaviors. Our analysis revealed comparable sociability levels between SHAM and OVX adult females. However, when we evaluated the habituation to a social stimulus, OVX mice exhibited increased sniffing of the stimulus in initial presentations, suggesting altered social novelty assessment. Our ongoing research aims to assess adult sociability in VPA-exposed females following ovariectomy at PD21, to evaluate the role of gonadal hormones on female resilience to VPA effects on sociability.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Author: Di Guardia Casella Luc\u00eda Mar\u00eda | email: lmdiguardiacasella@gmail.com | Disorders of the Nervous System<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[22],"class_list":["post-1316","post","type-post","status-publish","format-standard","hentry","category-session-1","tag-disorders-of-the-nervous-system"],"_links":{"self":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1316","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/comments?post=1316"}],"version-history":[{"count":4,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1316\/revisions"}],"predecessor-version":[{"id":2225,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1316\/revisions\/2225"}],"wp:attachment":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/media?parent=1316"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/categories?post=1316"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/tags?post=1316"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}