Disorders of the Nervous System<\/p>\n
Author:<\/strong> Clara Gaguine | Email:<\/strong> claragaguine@gmail.com<\/p>\n Clara Gaguine 1\u00b0<\/sup>, Indiana de Mar\u00eda P\u00e1ez Paz 1\u00b0<\/sup>, Mar\u00eda Elena Avale 1\u00b0<\/sup><\/p>\n 1\u00b0 INGEBI-CONICET<\/p>\n Tauopathies are neurodegenerative diseases associated with the abnormal metabolism of Tau protein, which leads to neuronal dysfunction and dementia symptoms. While Tau downregulation is a promising therapeutic strategy, global tau reduction might lead to undesired effects. Hence, developing more precise tools for Tau reduction only in affected neurons will enhance therapy efficiency and safety. Author: Gaguine Clara | email: claragaguine@gmail.com | Disorders of the Nervous System<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[22],"class_list":["post-1318","post","type-post","status-publish","format-standard","hentry","category-session-1","tag-disorders-of-the-nervous-system"],"_links":{"self":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1318","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/comments?post=1318"}],"version-history":[{"count":3,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1318\/revisions"}],"predecessor-version":[{"id":1803,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1318\/revisions\/1803"}],"wp:attachment":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/media?parent=1318"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/categories?post=1318"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/tags?post=1318"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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\nTwo fundamental characteristics of Tauopathies are \u0093selective neuronal vulnerability\u0094 and \u0093selective regional vulnerability\u0094, which indicate that the pathology affects specific neuronal types, and progressively impacts certain brain regions in a stereotyped and predictable manner.
\nThe general aim of this project is focused on understanding the mechanisms underlying selective vulnerability due to the post-transcriptional regulation of Tau. We aim to express effective Tau-reducing microRNAs (Facal et al., 2023), but in a cyto- site specific manner.
\nWe constructed lentiviral vectors (LVs) to achieve expression restricted to glutamatergic vs. GABAergic neurons, using engineered promoters for glutamatergic (CamKII) or GABAergic neurons (GAD67\/h56D). LVs carrying reporter genes were stereotactically injected into the mouse prefrontal cortex to analyze the expression in the injected areas.
\nFurther studies will involve specific expression of anti-Tau miRNAs in cultured human neurons and in a mouse model of tauopathy, to determine the outcomes of locally restricted tau downregulation.<\/p>\n","protected":false},"excerpt":{"rendered":"