Disorders of the Nervous System<\/p>\n
Author:<\/strong> Indiana de Mar\u00eda P\u00e1ez Paz | Email:<\/strong> indiana.m.p.p@gmail.com<\/p>\n Indiana de M P\u00e1ez Paz 1\u00b0<\/sup>, Carolina Facal 1\u00b0<\/sup>,\u00a0Monica Mezmezian 4\u00b0<\/sup>,\u00a0Gustavo Sevlever\u00a04\u00b0<\/sup>, Tom\u00e1s Falzone 2\u00b0<\/sup>, Blas Couto 3\u00b0<\/sup>, Gabriel Mizraji 3\u00b0<\/sup>, Avale Elena 1\u00b0<\/sup><\/p>\n 1\u00b0 INGEBI-CONICET Tauopathies, as Alzheimer\u0092s disease, progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), are neurodegenerative diseases characterized by the abnormal metabolism of Tau, which accumulates as insoluble hyperphosphorylated neuronal deposits. In each type of tauopathy, this process starts in certain brain nuclei and repeats a defined progression pattern, which gives rise to different clinical signs and symptoms, but some tauopathies present mixed phenotypes which makes the clinical diagnosis process complicated. Current diagnosis criteria do not absolutely differentiate among tauopathies from each other and from other neurodegenerative diseases. Thus, post-mortem analysis and its correlation with previously observed clinical signs is an utmost need to understand the molecular bases of each type of tauopathy and refine diagnosis. Author: P\u00e1ez Paz Indiana de Mar\u00eda | email: indiana.m.p.p@gmail.com | Disorders of the Nervous System<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[22],"class_list":["post-1324","post","type-post","status-publish","format-standard","hentry","category-session-1","tag-disorders-of-the-nervous-system"],"_links":{"self":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1324","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/comments?post=1324"}],"version-history":[{"count":4,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1324\/revisions"}],"predecessor-version":[{"id":2309,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1324\/revisions\/2309"}],"wp:attachment":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/media?parent=1324"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/categories?post=1324"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/tags?post=1324"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n
\n2\u00b0 IBioBA-CONICET and FMED-UBA
\n3\u00b0 INCyT- INECO-CONICET and Hospital Universitario Favaloro
\n4\u00b0 Laboratorio de Neuropatolog\u00eda y Biolog\u00eda Molecular, Banco de Cerebros, Fleni<\/p>\n
\nIn this project we address this issue through the analysis of post-mortem brain samples from patients diagnosed with primary tauopathies (PSP\/CBD) in Argentina. We analyze the presence of pathological Tau and changes in Tau isoforms contents in different regions of the brain. In further studies, we will determine MAPT mutations and local variants of candidate genes putatively affecting tau processing and their transcriptomic profile. We show here that one patient initially diagnosed with PSP presents an increase in Tau3R isoforms in basal ganglia and prefrontal cortex, suggesting a 3R tauopathy.<\/p>\n","protected":false},"excerpt":{"rendered":"