Neural Circuits and Systems Neuroscience<\/p>\n
Author:<\/strong> Constanza Ilarraz | Email:<\/strong> cilarraz@psi.uba.ar<\/p>\n Constanza Ilarraz 1\u00b0<\/sup>, Mar\u00eda Jes\u00fas Trujillo 1\u00b0<\/sup>, Mario Acu\u00f1a 3\u00b0<\/sup>, Agostina Presta 2\u00b0<\/sup>, Thomas Nevian 3\u00b0<\/sup>, Fernando Kasanetz 1\u00b0<\/sup><\/p>\n 1\u00b0 Universidad de Buenos Aires, Facultad de Ciencias M\u00e9dicas, Departamento de Ciencias Fisiol\u00f3gicas, Grupo de Neurociencia de Sistemas, Buenos Aires, Argentina The perception of pain is a multidimensional experience arising from distributed brain activity. However, how the brain encodes this experience remains elusive. Particularly, little is known about the neuronal mechanisms associated with the unpleasantness that characterizes pain. Author: Ilarraz Constanza | email: cilarraz@psi.uba.ar | Neural Circuits and Systems Neuroscience<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[23],"class_list":["post-1333","post","type-post","status-publish","format-standard","hentry","category-session-1","tag-neural-circuits-and-systems-neuroscience"],"_links":{"self":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1333","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/comments?post=1333"}],"version-history":[{"count":3,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1333\/revisions"}],"predecessor-version":[{"id":1837,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1333\/revisions\/1837"}],"wp:attachment":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/media?parent=1333"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/categories?post=1333"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/tags?post=1333"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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\n2\u00b0 CONICET – Universidad de Buenos Aires, Instituto de Fisiolog\u00eda y Biof\u00edsica Bernardo Houssay (IFIBIO Houssay), Buenos Aires, Argentina
\n3\u00b0 Department of Physiology, University of Bern, Bern, Switzerland<\/p>\n
\nA key structure for the affective processing of pain is the Anterior Cingulate Cortex (ACC). The dense excitatory connections between the ACC and the dorso-medial striatum may serve as a path for nociceptive information to the mesolimbic system, critical for the motivational modulation of behavior. Here we addressed the instrumental role of ACC cortico-striatal (ACC-CS) neurons in pain-related behaviors using a chemogenetic approach with inhibitory dreadds to interfere with their activity.
\nWe characterized in mice reflexive responses to noxious stimuli and more complex behaviors that reflect the subject\u0092s motivation to alleviate aversive sensations. Preliminary results indicate that the inhibition of ACC-CS neurons impaired the processing of pain-associated aversion. Thus, dreadd-treated mice showed a defective performance in a real-time conditioned place avoidance test, where control animals avoided spending time in a compartment paired with a noxious stimulus.
\nFinally, additional to extensive behavioral analysis, we are monitoring the activity of ACC-CS neurons through in vivo neuronal calcium imaging using a miniature microscope to discern their role in the encoding of pain-related behaviors.<\/p>\n","protected":false},"excerpt":{"rendered":"