Cellular and Molecular Neurobiology<\/p>\n
Author:<\/strong> ERIKA INES GEORGIEFF | Email:<\/strong> Georgiefferikaines@gmail.com<\/p>\n ERIKA GEORGIEFF 2\u00b0<\/sup>, CAROLINA ALBERCA 3\u00b0<\/sup>, JENNIFER MIRANDA 1\u00b0<\/sup>, MARIELA CHERTOFF 2\u00b0<\/sup><\/p>\n 1\u00b0 Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Qu\u00edmica Biol\u00f3gica, Laboratorio de Neuroepigen\u00e9tica, Buenos Aires, Argentina. Maternal malnutrition impacts brain development and long-term mental health, elevating Author: GEORGIEFF ERIKA INES | email: Georgiefferikaines@gmail.com | Cellular and Molecular Neurobiology<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[18],"class_list":["post-1889","post","type-post","status-publish","format-standard","hentry","category-session-2","tag-cellular-and-molecular-neurobiology"],"_links":{"self":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1889","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/comments?post=1889"}],"version-history":[{"count":2,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1889\/revisions"}],"predecessor-version":[{"id":2233,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1889\/revisions\/2233"}],"wp:attachment":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/media?parent=1889"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/categories?post=1889"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/tags?post=1889"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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\n2\u00b0 CONICET-Universidad de Buenos Aires, Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales \u0096 CONICET (IQUIBICEN), Buenos Aires, Argentina.
\n3\u00b0 Department of Neurological Surgery, University of Winconsin-Madison, USA<\/p>\n
\nthe risk to suffer of anxiety and depression disorders. DNA methylation is a key neuronal
\nmechanism for adapting to environmental changes. In this study, female mice exposed to
\nnormal-protein (NP) or low-protein (LP) diets during gestation and lactation were assessed
\nfor behavior and gene\/protein expression in mothers and female offspring. We observed
\nthat a LP diet in pregnancy and lactation led to anxiety-like behavior and anhedonia in
\nmothers and offspring. Reduced GR expression occurred in both hippocampus (HP) and
\namygdala (AMY) of mothers and LP offspring. we noted an increase in plasma
\ncorticosterone levels in offspring. Malnourished offspring displayed lower Bdnf exon VI and
\nan increase in the expression of Dnmt3b and Gadd45b in HP. AMY showed a trend
\ntowards reduced Dnmt3b. A 5mC dot blot in HP of mothers and offspring revealed no
\nfound differences between NP al LP animals on global 5mC levels. These findings indicate
\nHPA axis dysregulation in offspring, potentially increasing anxiety-like behaviors in adult
\nLP offspring.<\/p>\n","protected":false},"excerpt":{"rendered":"