Cellular and Molecular Neurobiology<\/p>\n
Author:<\/strong> Yael Macarena Peralta Cuasolo | Email:<\/strong> macafcq@gmail.com<\/p>\n Yael Macarena Peralta Cuasolo 1\u00b0<\/sup>, Sebasti\u00e1n Dupraz 2\u00b0<\/sup>, Nicolas Usain 3\u00b04\u00b0<\/sup>, Mariano Bisbal 3\u00b05\u00b0<\/sup>, Gonzalo Quassollo 3\u00b0<\/sup>, Mauricio R Galiano 1\u00b0<\/sup>, Diego Grassi 1\u00b0<\/sup>, Santiago Quiroga 1\u00b0<\/sup>, Lucas Javier Sosa 1\u00b0<\/sup><\/p>\n 1\u00b0 Departamento de Qu\u00edmica Biol\u00f3gica Ranwell Caputto, Facultad de Ciencias Qu\u00edmicas, CIQUIBIC-CONICET-Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina The development of the complex structure of the mammalian neocortex requires the Author: Peralta Cuasolo Yael Macarena | email: macafcq@gmail.com | Cellular and Molecular Neurobiology<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[18],"class_list":["post-1898","post","type-post","status-publish","format-standard","hentry","category-session-2","tag-cellular-and-molecular-neurobiology"],"_links":{"self":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1898","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/comments?post=1898"}],"version-history":[{"count":3,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1898\/revisions"}],"predecessor-version":[{"id":2271,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1898\/revisions\/2271"}],"wp:attachment":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/media?parent=1898"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/categories?post=1898"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/tags?post=1898"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n
\n2\u00b0 Axonal Growth and Regeneration, German Center for Neurodegenarative Diseases, Bonn, Germany
\n3\u00b0 Instituto de Investigaci\u00f3n M\u00e9dica Mercedes y Mart\u00edn Ferreyra (INIMEC), Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina
\n4\u00b0 Centro de Biolog\u00eda Celular y Molecular (CeBiCeM, FCEFyN-UNC), Facultad de Ciencias Exactas F\u00edsicas y Naturales, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina
\n5\u00b0 Instituto Universitario Ciencias Biom\u00e9dicas de C\u00f3rdoba (IUCBC), C\u00f3rdoba, Argentina<\/p>\n
\nproper migration of developing neurons from the ventricular zone containing neural
\nprogenitors to the cortical plate. The precise coordination of different cellular processes
\nsuch as cytoskeleton dynamics, membrane trafficking and cell adhesion during
\nmigration is achieved by a variety of signaling pathways. GTPases play a central role in
\nall these processes. The small GTPase Rab21 regulates migration and neurite growth in
\ndeveloping neurons. Moreover, regulators and effectors of Rab21 have been implicated
\nin brain pathologies with cortical malformations, suggesting a key function for the
\nRab21 signaling pathway in cortical development. Mechanistically, it has been posited
\nthat Rab21 influences cell migration by controlling the trafficking of endocytic vesicles
\ncontaining adhesion molecules. However, direct evidence of the participation of Rab21
\nor its mechanism of action in the regulation of cortical migration is still incomplete. In
\nthis study, we demonstrate that Rab21 plays a critical role in the differentiation and
\nmigration of pyramidal neurons by regulating the levels of the amyloid precursor
\nprotein on the neuronal cell surface. Rab21 loss of function increased the levels of
\nmembrane-exposed APP, resulting in impaired cortical neuronal differentiation and
\nmigration.<\/p>\n","protected":false},"excerpt":{"rendered":"