{"id":1922,"date":"2023-09-26T21:42:44","date_gmt":"2023-09-27T00:42:44","guid":{"rendered":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/2023\/09\/26\/088-effect-of-intracisternal-rad-igf1-in-anxiety-like-behavior-in-a-rat-model-of-neurotoxicity\/"},"modified":"2023-09-26T22:54:12","modified_gmt":"2023-09-27T01:54:12","slug":"088-effect-of-intracisternal-rad-igf1-in-anxiety-like-behavior-in-a-rat-model-of-neurotoxicity","status":"publish","type":"post","link":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/2023\/09\/26\/088-effect-of-intracisternal-rad-igf1-in-anxiety-like-behavior-in-a-rat-model-of-neurotoxicity\/","title":{"rendered":"088 | EFFECT OF INTRACISTERNAL RAD-IGF1 IN ANXIETY-LIKE BEHAVIOR IN A RAT MODEL OF NEUROTOXICITY"},"content":{"rendered":"<p>Cognition, Behavior, and Memory<\/p>\n<p><strong>Author:<\/strong> Leandro Champarini | <strong>Email:<\/strong> leandro.champarini@unc.edu.ar<\/p>\n<hr \/>\n<p>Leandro Gabriel Champarini <sup>1\u00b0<\/sup>, Macarena Lorena Herrera <sup>1\u00b0<\/sup>, Mat\u00edas Javega Cometto <sup>1\u00b0<\/sup>, Aracely Naranjo Viteri <sup>1\u00b0<\/sup>, Rosana Crespo <sup>1\u00b0<\/sup>, Gast\u00f3n Diego Calfa <sup>1\u00b0<\/sup>, Claudia Beatriz Here\u00f1\u00fa <sup>1\u00b0<\/sup><\/p>\n<p>1\u00b0 Instituto de Farmacolog\u00eda Experimental C\u00f3rdoba (IFEC-CONICET) &#8211; Departamento de Farmacolog\u00eda Otto Orsingher. Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina.<\/p>\n<p>Parkinson&#8217;s disease is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons, resulting in a range of motor and non-motor symptoms. Although motor deficits are the main criteria for diagnosis, there is growing evidence that non-motor symptoms may also play an important role in the disease progression. We aimed to investigate the possible effect of IGF-1 in the progression of emotional-like behavior deficits in a rat model of neurotoxicity inducedby 6-OHDA infusion into the dorsolateral striatum. We assessed the behavioral changes in male Wistar rats after 1, 2 and 3 weeks post-lesion using the elevated plus maze, light-dark box, and forced swimming tests. After 6-OHDA infusion, immunohistochemical analysis revealed a decrease in tyrosine hydroxylase immunoreactivity in the substantia nigra, ventral tegmental area, and striatum, indicating partial lesion of the nigrostriatal dopaminergic system. Furthermore, we found an increase in mRNA levels of proinflammatory cytokines IL-1 in the striatum. Our results showed anxiety-like behavior at 2 and 3 weeks post-lesion, beforethe onset of motor impairment. And IGF-1 was able to prevent such behavior at week 3.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Author: Champarini Leandro | email: leandro.champarini@unc.edu.ar | Cognition, Behavior, and Memory<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[20],"class_list":["post-1922","post","type-post","status-publish","format-standard","hentry","category-session-2","tag-cognition-behavior-and-memory"],"_links":{"self":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1922","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/comments?post=1922"}],"version-history":[{"count":1,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1922\/revisions"}],"predecessor-version":[{"id":2075,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1922\/revisions\/2075"}],"wp:attachment":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/media?parent=1922"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/categories?post=1922"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/tags?post=1922"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}