Cognition, Behavior, and Memory<\/p>\n
Author:<\/strong> Juan Gabriel Riboldi | Email:<\/strong> juangriboldi@gmail.com<\/p>\n Juan Gabriel Riboldi 1\u00b02\u00b03\u00b0<\/sup>, Julieta Correa 1\u00b02\u00b03\u00b0<\/sup>, Mat\u00edas Renfijes 1\u00b02\u00b0<\/sup>, Haydee Viola 1\u00b02\u00b03\u00b0<\/sup><\/p>\n 1\u00b0 Facultad de Medicina, Instituto de Biolog\u00eda Celular y Neurociencia “Prof. E. De Robertis” (IBCN), UBA-CONICET, Buenos Aires, Argentina This study aimed to investigate the role of glutamate transporter GLT\u00961, located in astrocytes, in spatial memory consolidation, expression, and reconsolidation, along with exploring the cellular mechanisms that occur under GLT-1 blockage. We used the spatial object recognition (SOR) task in rats, and administered dihydrokainic acid (DHK), a selective GLT-1 inhibitor, in the dorsal hippocampus. While a strong training session induced long-term memory (LTM) formation, a weak training session induced short-term memory. Inhibiting GLT-1 around a weak SOR training session promoted SOR-LTM formation. This effect was prevented by the administration of a protein-synthesis inhibitor. Moreover, SOR-LTM promotion by DHK was dependent on hippocampal activity-related cytoskeletal protein (Arc) translation and on brain-derived neurotrophic factor (BDNF) action, plasticity related proteins necessary for memory consolidation. Alternatively, DHK administration before a test session impaired SOR-LTM expression. This effect was prevented if Arc translation was pharmacologically blocked, but not by inhibiting BDNF action. Furthermore, if applied before a reactivation session, DHK impaired reconsolidation and this effect was not reversed by Arc translation inhibition. Author: Riboldi Juan Gabriel | email: juangriboldi@gmail.com | Cognition, Behavior, and Memory<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[20],"class_list":["post-1952","post","type-post","status-publish","format-standard","hentry","category-session-2","tag-cognition-behavior-and-memory"],"_links":{"self":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1952","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/comments?post=1952"}],"version-history":[{"count":4,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1952\/revisions"}],"predecessor-version":[{"id":2297,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1952\/revisions\/2297"}],"wp:attachment":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/media?parent=1952"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/categories?post=1952"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/tags?post=1952"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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\n2\u00b0 Instituto Tecnol\u00f3gico de Buenos Aires, Buenos Aires, Argentina
\n3\u00b0 Departamento de Fisiolog\u00eda, Facultad de Ciencias Exactas y Naturales, Biolog\u00eda Molecular y Celular “Dr. H\u00e9ctor Maldonado” (FBMC), University of Buenos Aires (UBA), Buenos Aires, Argentina<\/p>\n
\nThese findings reveal that hippocampal Arc and BDNF play a pivotal role in spatial memory processes, shedding light on the intricate molecular mechanisms of memory processes, governed by the activity of both neurons and glia.<\/p>\n","protected":false},"excerpt":{"rendered":"