Disorders of the Nervous System<\/p>\n
Author:<\/strong> Diego Flores Luna | Email:<\/strong> biodiegoflores@gmail.com<\/p>\n Diego Flores-Luna 1\u00b0<\/sup>, Ximena L\u00f3pex-Hill 1\u00b0<\/sup>, Anal\u00eda Richeri 1\u00b0<\/sup>, Sara Fabius 1\u00b0<\/sup>, Gaby Mart\u00ednez 1\u00b0<\/sup>, Jessica Urbanavicius 1\u00b0<\/sup>, Ronald McGregor 2\u00b0<\/sup>, Cecilia Scorza 1\u00b0<\/sup><\/p>\n 1\u00b0 Departamento de Neurofarmacolog\u00eda Experimental, Instituto de Investigaciones Clemente Estable, Montevideo, Uruguay Cannabidiol (CBD), a non-psychotomimetic cannabinoid from the plant Cannabis sativa, has been proposed as a potential candidate for the treatment of cocaine use disorders; however contradictory data exist. Our previous studies, have shown that street-seized smoked cocaine samples were frequently adulterated with caffeine. We demonstrated that caffeine accelerates and enhances the cocaine-induced locomotor sensitization in rodents. Pretreatment of CBD attenuated this effect, supporting its therapeutic potential. It is well-known that the expression of psychostimulant-induced locomotor sensitization is associated with neuroinflammatory processes, involving the microglial reactivity. Regarding the CBD anti-inflammatory property, we hypothesized that CBD prevents the cocaine and caffeine-induced neuroinflammatory process and helps to attenuate the sensitization. Male adult mice were treated with CBD (20 mg\/kg\/i.p.) and CocCaf (5:2.5 mg\/kg) or its respective vehicles for 5 days. Locomotor activity was recorded in an open field by the video-tracking software EthoVision XT 17.0. Microglial reactivity in the nucleus accumbens (NAc) was evaluated by anti-Iba1 immunofluorescence (microglial marker). As expected, CocCaf-induced locomotor sensitization was accompanied by an increase in Iba-1 immunoreactivity in the NAc. However, CBD did not attenuate the behavioral effects. It remains to be tested whether CBD attenuates the neuroinflammation associated with behavioral sensitization.<\/p>\n","protected":false},"excerpt":{"rendered":" Author: Flores Luna Diego | email: biodiegoflores@gmail.com | Disorders of the Nervous System<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[22],"class_list":["post-1969","post","type-post","status-publish","format-standard","hentry","category-session-2","tag-disorders-of-the-nervous-system"],"_links":{"self":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1969","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/comments?post=1969"}],"version-history":[{"count":1,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1969\/revisions"}],"predecessor-version":[{"id":2128,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1969\/revisions\/2128"}],"wp:attachment":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/media?parent=1969"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/categories?post=1969"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/tags?post=1969"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n
\n2\u00b0 Center for Sleep Research, Department of Psychiatry, School of Medicine, University of California, USA<\/p>\n