Disorders of the Nervous System<\/p>\n
Author:<\/strong> Araceli Seiffe | Email:<\/strong> aseiffe@gmail.com<\/p>\n Araceli Seiffe 1\u00b02\u00b0<\/sup>, Amaicha Mara Depino 1\u00b02\u00b0<\/sup><\/p>\n 1\u00b0 IFIBYNE, UBA-CONICET, CABA, Argentina Autism spectrum disorders (ASD) are characterized by reduced sociability and repetitive behaviors. Notably, this disorder is approximately 4 times more prevalent in boys than girls. To investigate this bias, we used a mouse model: valproic acid (VPA). This model is particularly interesting because it mirrors the gender bias seen in humans. Author: Seiffe Araceli | email: aseiffe@gmail.com | Disorders of the Nervous System<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[22],"class_list":["post-1979","post","type-post","status-publish","format-standard","hentry","category-session-2","tag-disorders-of-the-nervous-system"],"_links":{"self":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1979","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/comments?post=1979"}],"version-history":[{"count":2,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1979\/revisions"}],"predecessor-version":[{"id":2247,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1979\/revisions\/2247"}],"wp:attachment":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/media?parent=1979"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/categories?post=1979"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/tags?post=1979"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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\n2\u00b0 DBBE, FCEN, University of Buenos Aires, CABA, Argentina<\/p>\n
\nOur hypothesis posits that the process of brain masculinization is necessary for VPA to impact autism-related behaviors. To test this, in the VPA model, we injected pups with 5 \u00b5g 17\u03b2-estradiol benzoate (E2) on postnatal days 2, 5, and 8, replicating the testosterone surge males experience during early development.
\nWhen we analyzed juvenile behavior, we observed that VPA-exposed females displayed altered social behavior, with the phenotype rescued by estradiol exposure. Conversely, in adulthood we observed that VPA-E2 females did not habituate to social stimuli in both the social interaction test and the social habituation and novelty recognition task.
\nBy assessing different parameters including ovaries development, sexually dimorphic brain nuclei and hormone concentrations in plasma, we were able to validate the successful implementation of the masculinization protocol. Other areas relevant to the model\u0097such as the cerebellum, CA2 region of the hippocampus, and piriform cortex\u0097showed no differences between the groups.
\nIn summary, we can affirm that gonadal hormones drive ASD sex bias, impacting perinatal and juvenile stages.<\/p>\n","protected":false},"excerpt":{"rendered":"