Neurochemistry and Neuropharmacology<\/p>\n
Author:<\/strong> Lucia Ag\u00fcero | Email:<\/strong> lucia@ague.ro<\/p>\n Lucia Ag\u00fcero 1\u00b0<\/sup>, Sofia Ludmila Gallino 1\u00b0<\/sup>, Viviana Karina Dalamon 1\u00b0<\/sup>, Mar\u00eda Eugenia G\u00f3mez Casati 2\u00b0<\/sup>, Ana Bel\u00e9n Elgoyhen 1\u00b02\u00b0<\/sup><\/p>\n 1\u00b0 Instituto de Investigaciones en Ingenier\u00eda Gen\u00e9tica y Biolog\u00eda Molecular (INGEBI) Hearing loss affects 360 million people (5% of the world’s population and 42% of the population over 75 years of age). While half of hearing loss is genetic in origin, the other 50% is due to environmental conditions. Among them, prolonged exposure to loud noise is the main cause of hearing loss. One of the main challenges in the field of hearing is to find a pharmacotherapeutic strategy to prevent the damage produced by noisy environments, when these cannot be avoided. Recent studies have postulated the \u03b19\u03b110 nicotinic cholinergic receptor present in the sensory hair cells of the cochlea as a therapeutic target for the development of drugs that increase the activity of the olivocochlear efferent system, in order to prevent acoustic trauma. The aim of this work is to test possible positive allosteric modulators (PAMs) of \u03b19\u03b110 and their potential to prevent hearing loss due to the exposure to loud noise. To this end, we tested several candidates for PAMs or agonists of certain receptors that are closely or distantly related to \u03b19\u03b110 such as \u03b17, \u03b14\u03b22 or \u03b14\u03b24 and serotonin receptors in recombinant \u03b19\u03b110 receptors expressed in Xenopus laevis oocytes. Up to this point, Chlorophenyl biguanide, a selective serotonin receptor agonist, has been evaluated; also Ivermectin and TQS, PAMs of \u03b17 nAChRs; NS-9283, an \u03b14\u03b22 nAChR PAM; and LY\u20132087101 PAM of \u03b17, \u03b14\u03b22 and \u03b14\u03b24 nAChRs which did not positively modulate the \u03b19\u03b110 receptor.<\/p>\n","protected":false},"excerpt":{"rendered":" Author: Ag\u00fcero Lucia | email: lucia@ague.ro | Neurochemistry and Neuropharmacology<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[25],"class_list":["post-1994","post","type-post","status-publish","format-standard","hentry","category-session-2","tag-neurochemistry-and-neuropharmacology"],"_links":{"self":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1994","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/comments?post=1994"}],"version-history":[{"count":3,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1994\/revisions"}],"predecessor-version":[{"id":2419,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/1994\/revisions\/2419"}],"wp:attachment":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/media?parent=1994"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/categories?post=1994"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/tags?post=1994"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n
\n2\u00b0 Instituto de Farmacolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires<\/p>\n