{"id":2006,"date":"2023-09-26T21:42:49","date_gmt":"2023-09-27T00:42:49","guid":{"rendered":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/2023\/09\/26\/256-odor-mixture-detection-in-drosophila-melanogaster\/"},"modified":"2023-09-28T16:37:51","modified_gmt":"2023-09-28T19:37:51","slug":"256-odor-mixture-detection-in-drosophila-melanogaster","status":"publish","type":"post","link":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/2023\/09\/26\/256-odor-mixture-detection-in-drosophila-melanogaster\/","title":{"rendered":"256 | Odor mixture detection in Drosophila melanogaster"},"content":{"rendered":"<p>Sensory and Motor Systems<\/p>\n<p><strong>Author:<\/strong> Lautaro Alejandro Duarte | <strong>Email:<\/strong> Duartelautaro5@gmail.com<\/p>\n<hr \/>\n<p>Lautaro Alejandro Duarte <sup>1\u00b0<\/sup>, Martin Klappenbach <sup>1\u00b02<\/sup><sup>\u00b0<\/sup>, Nicol\u00e1s P\u00edrez <sup>1\u00b02\u00b0<\/sup>, Fernando Locatelli <sup>1\u00b02\u00b0<\/sup><\/p>\n<p>1\u00b0 Instituto de Fisiolog\u00eda, Biolog\u00eda Molecular y Neurociencias; UBA-CONICET, Argentina.<br \/>\n2\u00b0 Departamento de Fisiolog\u00eda, Biolog\u00eda Molecular y Celular; Facultad de Ciencias Exactas y Naturales; Universidad de Buenos Aires, Argentina.<\/p>\n<p>Odorants are detected by olfactory receptor neurons (ORNs) that project to the antennal lobe<br \/>\n(AL), the first olfactory neuropil in the insect brain. In the AL, ORNs make synaptic contacts<br \/>\nwith: i) projection neurons (PNs) that send olfactory information to other brain areas; and ii)<br \/>\nlocal interneurons (LNs) that form a dense network of lateral interactions within the AL.<br \/>\nFunctional studies indicate that this network reshapes sensory information, presumably to<br \/>\nenhance perception of meaningful odors. In this project we investigate the role of GABAergic<br \/>\ninteractions in relation to learning dependent neural plasticity in the AL. Our previous work<br \/>\nshowed that the representation of a mixture in the AL changes after aversive conditioning,<br \/>\nmaking the learned component more salient. Now we are performing aversive olfactory<br \/>\nconditioning using a T-maze. We train flies to associate an electric shock with an odor that they<br \/>\nhave to avoid during the test session. To study how animals perceive mixtures, we evaluate<br \/>\nthe ability of the animals to detect the presence of the learned odor immersed in a binary<br \/>\nmixture. To do that, we test the flies with two stimuli: a novel odor versus a mixture that<br \/>\ncontains the associated odor. Future experiments are directed to evaluate whether blocking<br \/>\nthe LNs activity impairs learning dependent changes and the ability to detect learned<br \/>\ncomponent.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Author: Duarte Lautaro Alejandro | email: Duartelautaro5@gmail.com | Sensory and Motor Systems<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[27],"class_list":["post-2006","post","type-post","status-publish","format-standard","hentry","category-session-2","tag-sensory-and-motor-systems"],"_links":{"self":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/2006","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/comments?post=2006"}],"version-history":[{"count":2,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/2006\/revisions"}],"predecessor-version":[{"id":2257,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/posts\/2006\/revisions\/2257"}],"wp:attachment":[{"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/media?parent=2006"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/categories?post=2006"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/csan2023.saneurociencias.org.ar\/index.php\/wp-json\/wp\/v2\/tags?post=2006"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}