045 | Etv5 is involved in the maturation of adult dentate gyrus newborn neurons.

Cellular and Molecular Neurobiology

Author: Antonella Soledad Rios | Email: arios@leloir.org.ar

Antonella Soledad Ríos , Solana Florencia López , Gustavo Paratcha , Fernanda Ledda

1° Fundación Instituto Leloir, Instituto de Investigaciones Bioquímicas de Buenos Aires, CONICET, Buenos Aires, Argentina
2° División de Neurociencia Molecular y Celular, Instituto de Biología Celular y Neurociencias, Universidad de Buenos Aires, CONICET, Buenos Aires, Argentina

Generation of new neurons in adult mammals is restricted to discrete regions of the central nervous system, the subventricular zone (SVZ) of the lateral ventricles, and the subgranular zone (SGZ) of the hippocampal dentate gyrus (DG). Adult neural stem cell population, known as radial glia cell like (RGLs), have self-renewal capacity which is highly controlled by different factors. These cells can generate intermediate progenitors that pass through several well characterized developmental stages before they become mature granular cells (GCs). Functional integration of these new neurons into the preexisting circuits requires dendrite and axonal growth, and synapse formation. Here, we show that the Pea3 transcription factor, Etv5, is expressed in the postmitotic cells, committed to the neuronal linage during hippocampal adult neurogenesis. We observed that ablation of Etv5 in adult-neuronal precursors results in a delay in GCs maturation, impairs the dendritic morphological development and spine dendrite maturation of adult-born neurons in vivo. In summary, our data, indicates that Etv5 plays a key role in the development and the plasticity of newly generated neurons.