077 | Calcium imaging in CA3 in object recognition task

Cognition, Behavior, and Memory

Author: Sabrina Soledad Benas | Email: sabrinabenas@gmail.com

Sabrina Benas , Emilio Kropff

1° Buenos Aires University
2° Fundacion Instituto Leloir

The hippocampus plays an important role in memory and spatial orientation. In particular, it has been shown that DG avoids interference between similar memories but the mechanism is unknown. Here, we hypothesize that the information encoding is modulated by the demand for pattern separation in the DG-CA3 circuit. To explore this possibility, we performed calcium imaging recordings in CA3 with the miniscope in a behavioral task that required pattern separation and object recognition. Our preliminary results hint to a decrease in neuronal correlation in close objects than in far ones.